2w2n: Difference between revisions

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{{Seed}}
[[Image:2w2n.png|left|200px]]
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{{STRUCTURE_2w2n|  PDB=2w2n  |  SCENE=  }}  
{{STRUCTURE_2w2n|  PDB=2w2n  |  SCENE=  }}  
===WT PCSK9-DELTAC BOUND TO EGF-A H306Y MUTANT OF LDLR===
===WT PCSK9-DELTAC BOUND TO EGF-A H306Y MUTANT OF LDLR===
{{ABSTRACT_PUBMED_19001363}}


==Disease==
[[http://www.uniprot.org/uniprot/LDLR_HUMAN LDLR_HUMAN]] Defects in LDLR are the cause of familial hypercholesterolemia (FH) [MIM:[http://omim.org/entry/143890 143890]]; a common autosomal semi-dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis).<ref>PMID:3263645</ref><ref>PMID:2569482</ref><ref>PMID:3955657</ref><ref>PMID:8347689</ref><ref>PMID:2318961</ref><ref>PMID:1446662</ref><ref>PMID:1867200</ref><ref>PMID:8462973</ref><ref>PMID:8168830</ref><ref>PMID:2726768</ref><ref>PMID:1464748</ref><ref>PMID:7573037</ref><ref>PMID:7583548</ref><ref>PMID:7550239</ref><ref>PMID:7635461</ref><ref>PMID:7635482</ref><ref>PMID:7649546</ref><ref>PMID:7649549</ref><ref>PMID:8740918</ref><ref>PMID:8664907</ref><ref>PMID:9026534</ref><ref>PMID:9254862</ref><ref>PMID:9143924</ref><ref>PMID:9259195</ref><ref>PMID:9104431</ref><ref>PMID:9654205</ref><ref>PMID:9452094</ref><ref>PMID:9452095</ref><ref>PMID:9452118</ref><ref>PMID:10206683</ref><ref>PMID:10660340</ref>[:]<ref>PMID:9852677</ref><ref>PMID:9678702</ref><ref>PMID:10422803</ref><ref>PMID:10090484</ref><ref>PMID:10447263</ref><ref>PMID:10978268</ref><ref>PMID:10980548</ref><ref>PMID:10882754</ref><ref>PMID:11298688</ref><ref>PMID:17142622</ref><ref>PMID:19319977</ref><ref>PMID:22160468</ref>


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_19001363}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/LDLR_HUMAN LDLR_HUMAN]] Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
(as it appears on PubMed at http://www.pubmed.gov), where 19001363 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_19001363}}


==About this Structure==
==About this Structure==
2W2N is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2N OCA].  
[[2w2n]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2N OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:19001363</ref><references group="xtra"/>
<ref group="xtra">PMID:019001363</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Baysarowich, J.]]
[[Category: Baysarowich, J.]]
Line 47: Line 37:
[[Category: Familial hypercholesterolemia]]
[[Category: Familial hypercholesterolemia]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Hydrolase/receptor]]
[[Category: Hydrolase-receptor complex]]
[[Category: Ldlr]]
[[Category: Ldlr]]
[[Category: Lipid metabolism]]
[[Category: Lipid metabolism]]
Line 57: Line 47:
[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Steroid metabolism]]
[[Category: Steroid metabolism]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:25:11 2010''
Retrieved from "https://proteopedia.org/2w2n"