2f90: Difference between revisions
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{{STRUCTURE_2f90| PDB=2f90 | SCENE= }} | {{STRUCTURE_2f90| PDB=2f90 | SCENE= }} | ||
===Crystal structure of bisphosphoglycerate mutase in complex with 3-phosphoglycerate and AlF4-=== | |||
{{ABSTRACT_PUBMED_17052986}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/PMGE_HUMAN PMGE_HUMAN]] Defects in BPGM are the cause of bisphosphoglycerate mutase deficiency (BPGMD) [MIM:[http://omim.org/entry/222800 222800]]. A disease characterized by hemolytic anemia, splenomegaly, cholelithiasis and cholecystitis.<ref>PMID:2542247</ref><ref>PMID:1421379</ref><ref>PMID:15054810</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PMGE_HUMAN PMGE_HUMAN]] Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017052986</ref><references group="xtra"/> | <ref group="xtra">PMID:017052986</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Gong, W.]] | [[Category: Gong, W.]] | ||
