3v3l: Difference between revisions

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~~[[Image:3v3l.jpg|left|200px]]~~

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===Crystal structure of human RNF146 WWE domain in complex with iso-ADPRibose===

==Disease==

[[http://www.uniprot.org/uniprot/RN146_HUMAN RN146_HUMAN]] Note=Defects in RNF146 are a cause of susceptibility to breast cancer.

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==Function==

~~The line below this paragraph, {{ABSTRACT_PUBMED_22267412}}, adds the Publication Abstract to the page~~

[[http://www.uniprot.org/uniprot/RN146_HUMAN RN146_HUMAN]] E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.<ref>PMID:21478859</ref><ref>PMID:21602803</ref><ref>PMID:21799911</ref><ref>PMID:21825151</ref><ref>PMID:22267412</ref>

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 22267412~~ is the ~~PubMed ID number~~.

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~~{{ABSTRACT_PUBMED_22267412}}~~

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Cheng, Z.]]

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@@ Line 1: / Line 1: @@
-[[Image:3v3l.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3v3l", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3v3l|  PDB=3v3l  |  SCENE=  }}
 ===Crystal structure of human RNF146 WWE domain in complex with iso-ADPRibose===
+{{ABSTRACT_PUBMED_22267412}}
+==Disease==
+[[http://www.uniprot.org/uniprot/RN146_HUMAN RN146_HUMAN]] Note=Defects in RNF146 are a cause of susceptibility to breast cancer.
-<!--
+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_22267412}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/RN146_HUMAN RN146_HUMAN]] E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.<ref>PMID:21478859</ref><ref>PMID:21602803</ref><ref>PMID:21799911</ref><ref>PMID:21825151</ref><ref>PMID:22267412</ref>
-(as it appears on PubMed at http://www.pubmed.gov), where 22267412 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_22267412}}
 ==About this Structure==
@@ Line 22: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:022267412</ref><references group="xtra"/>
+<ref group="xtra">PMID:022267412</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Cheng, Z.]]