2nz0: Difference between revisions
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{{STRUCTURE_2nz0| PDB=2nz0 | SCENE= }} | {{STRUCTURE_2nz0| PDB=2nz0 | SCENE= }} | ||
===Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target)=== | |||
{{ABSTRACT_PUBMED_17187064}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/KCND3_HUMAN KCND3_HUMAN]] Note=KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS).<ref>PMID:22457051</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/KCIP1_HUMAN KCIP1_HUMAN]] Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface.<ref>PMID:10676964</ref><ref>PMID:11423117</ref><ref>PMID:12829703</ref> [[http://www.uniprot.org/uniprot/KCND3_HUMAN KCND3_HUMAN]] Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.<ref>PMID:9843794</ref><ref>PMID:10200233</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017187064</ref><references group="xtra"/> | <ref group="xtra">PMID:017187064</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chen, L.]] | [[Category: Chen, L.]] | ||
