2doa: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "2doa" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_2doa| PDB=2doa | SCENE= }} | {{STRUCTURE_2doa| PDB=2doa | SCENE= }} | ||
===Solution structure of the helical domain in human Eleven-nineteen lysine-rich leukemia protein ELL=== | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Note=A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ELL_HUMAN ELL_HUMAN]] Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.<ref>PMID:8596958</ref><ref>PMID:16006523</ref><ref>PMID:20471948</ref><ref>PMID:20159561</ref><ref>PMID:22252557</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. | [[2doa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOA OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Inoue, M.]] | [[Category: Inoue, M.]] | ||
