1i7e: Difference between revisions
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m Protected "1i7e" [edit=sysop:move=sysop] |
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{{STRUCTURE_1i7e| PDB=1i7e | SCENE= }} | {{STRUCTURE_1i7e| PDB=1i7e | SCENE= }} | ||
===C-Terminal Domain Of Mouse Brain Tubby Protein bound to Phosphatidylinositol 4,5-bis-phosphate=== | |||
{{ABSTRACT_PUBMED_11375483}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/TUB_MOUSE TUB_MOUSE]] Note=Defects in Tub are the cause of maturity-onset obesity, insulin resistance and sensory deficits. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TUB_MOUSE TUB_MOUSE]] Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity).<ref>PMID:10591637</ref><ref>PMID:11375483</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:011375483</ref><references group="xtra"/> | <ref group="xtra">PMID:011375483</ref><references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Baird, C L.]] | [[Category: Baird, C L.]] | ||
