2kny: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "2kny" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_2kny| PDB=2kny | SCENE= }} | {{STRUCTURE_2kny| PDB=2kny | SCENE= }} | ||
===Fusion construct of CR17 from LRP-1 and ApoE residues 130-149=== | ===Fusion construct of CR17 from LRP-1 and ApoE residues 130-149=== | ||
{{ABSTRACT_PUBMED_20303980}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LRP1_HUMAN LRP1_HUMAN]] Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.<ref>PMID:1702392</ref><ref>PMID:1618748</ref><ref>PMID:11907044</ref><ref>PMID:12888553</ref><ref>PMID:12713657</ref> Functions as a receptor for Pseudomonas aeruginosa exotoxin A.<ref>PMID:1702392</ref><ref>PMID:1618748</ref><ref>PMID:11907044</ref><ref>PMID:12888553</ref><ref>PMID:12713657</ref> | |||
==About this Structure== | ==About this Structure== | ||
| Line 11: | Line 10: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020303980</ref><references group="xtra"/> | <ref group="xtra">PMID:020303980</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Guttman, M.]] | [[Category: Guttman, M.]] | ||
