1pdg: Difference between revisions
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{{STRUCTURE_1pdg| PDB=1pdg | SCENE= }} | {{STRUCTURE_1pdg| PDB=1pdg | SCENE= }} | ||
===CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB=== | |||
{{ABSTRACT_PUBMED_1396586}} | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN]] Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.<ref>PMID:12660034</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN]] Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:001396586</ref><references group="xtra"/> | <ref group="xtra">PMID:001396586</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Darcy, A D.]] | [[Category: Darcy, A D.]] | ||
