2per: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_2per| PDB=2per | SCENE= }} | {{STRUCTURE_2per| PDB=2per | SCENE= }} | ||
===Crystal Structure of Human Chloride Intracellular Channel protein 2=== | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN]] Note=Defects in CLIC2 are a cause of a mental retardation with cardiopathy and seizures. Cardiac features include atrial fibrillation, cardiomegaly, and congestive heart failure. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN]] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.<ref>PMID:15147738</ref><ref>PMID:15916532</ref><ref>PMID:17945253</ref> | |||
==About this Structure== | ==About this Structure== | ||
| Line 13: | Line 15: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018186468</ref><references group="xtra"/> | <ref group="xtra">PMID:018186468</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Liang, Y H.]] | [[Category: Liang, Y H.]] | ||
