2dix: Difference between revisions

Line 1:

~~[[Image:2dix.png|left|200px]]~~

===Solution structure of the DSRM domain of Protein activator of the interferon-induced protein kinase===

===~~Solution structure~~ of the ~~DSRM domain~~ of ~~Protein activator of the interferon~~-~~induced protein kinase===~~

==Disease==

[[http://www.uniprot.org/uniprot/PRKRA_HUMAN PRKRA_HUMAN]] Defects in PRKRA are the cause of dystonia type 16 (DYT16) [MIM:[http://omim.org/entry/612067 612067]]. DYT16 is an early-onset dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT16 patients have progressive, generalized dystonia with axial muscle involvement, oro-mandibular (sardonic smile) and laryngeal dystonia and, in some cases, parkinsonian features.<ref>PMID:18243799</ref><ref>PMID:18420150</ref>

==Function==

[[http://www.uniprot.org/uniprot/PRKRA_HUMAN PRKRA_HUMAN]] Activates EIF2AK2/PKR in the absence of double stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1.<ref>PMID:9687506</ref><ref>PMID:10336432</ref><ref>PMID:11238927</ref><ref>PMID:16424907</ref><ref>PMID:16982605</ref><ref>PMID:17452327</ref>

==About this Structure==

[[2dix]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DIX OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Dang, W.]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2dix.png|left|200px]]
 {{STRUCTURE_2dix|  PDB=2dix  |  SCENE=  }}
+===Solution structure of the DSRM domain of Protein activator of the interferon-induced protein kinase===
-===Solution structure of the DSRM domain of Protein activator of the interferon-induced protein kinase===
+==Disease==
+[[http://www.uniprot.org/uniprot/PRKRA_HUMAN PRKRA_HUMAN]] Defects in PRKRA are the cause of dystonia type 16 (DYT16) [MIM:[http://omim.org/entry/612067 612067]]. DYT16 is an early-onset dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT16 patients have progressive, generalized dystonia with axial muscle involvement, oro-mandibular (sardonic smile) and laryngeal dystonia and, in some cases, parkinsonian features.<ref>PMID:18243799</ref><ref>PMID:18420150</ref>
+==Function==
+[[http://www.uniprot.org/uniprot/PRKRA_HUMAN PRKRA_HUMAN]] Activates EIF2AK2/PKR in the absence of double stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1.<ref>PMID:9687506</ref><ref>PMID:10336432</ref><ref>PMID:11238927</ref><ref>PMID:16424907</ref><ref>PMID:16982605</ref><ref>PMID:17452327</ref>
 ==About this Structure==
 [[2dix]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DIX OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Dang, W.]]