1irs: Difference between revisions

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~~[[Image:1irs.png|left|200px]]~~

===IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE===

===~~IRS~~-~~1 PTB DOMAIN COMPLEXED WITH A IL~~-~~4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE===~~

==Disease==

[[http://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[http://omim.org/entry/125853 125853]].<ref>PMID:14707024</ref><ref>PMID:8723689</ref><ref>PMID:10206679</ref><ref>PMID:12843189</ref><ref>PMID:15590636</ref>

~~{{ABSTRACT_PUBMED_8599766}}~~

==Function==

[[http://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).<ref>PMID:16878150</ref><ref>PMID:14707024</ref> [[http://www.uniprot.org/uniprot/IL4RA_HUMAN IL4RA_HUMAN]] Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.<ref>PMID:8124718</ref> Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.<ref>PMID:8124718</ref>

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Feisk, S W.]]

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@@ Line 1: / Line 1: @@
-[[Image:1irs.png|left|200px]]
 {{STRUCTURE_1irs|  PDB=1irs  |  SCENE=  }}
+===IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE===
+{{ABSTRACT_PUBMED_8599766}}
-===IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE===
+==Disease==
+[[http://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[http://omim.org/entry/125853 125853]].<ref>PMID:14707024</ref><ref>PMID:8723689</ref><ref>PMID:10206679</ref><ref>PMID:12843189</ref><ref>PMID:15590636</ref>
-{{ABSTRACT_PUBMED_8599766}}
+==Function==
+[[http://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN]] May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).<ref>PMID:16878150</ref><ref>PMID:14707024</ref> [[http://www.uniprot.org/uniprot/IL4RA_HUMAN IL4RA_HUMAN]] Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.<ref>PMID:8124718</ref>  Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.<ref>PMID:8124718</ref>
 ==About this Structure==
@@ Line 11: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:008599766</ref><references group="xtra"/>
+<ref group="xtra">PMID:008599766</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Feisk, S W.]]