2g59: Difference between revisions
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{{STRUCTURE_2g59| PDB=2g59 | SCENE= }} | {{STRUCTURE_2g59| PDB=2g59 | SCENE= }} | ||
===Crystal Structure of the Catalytic Domain of Protein Tyrosine Phosphatase from Homo sapiens=== | |||
{{ABSTRACT_PUBMED_18058037}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/PTPRO_HUMAN PTPRO_HUMAN]] Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6) [MIM:[http://omim.org/entry/614196 614196]]. NPHS6 is a renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure.<ref>PMID:21722858</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PTPRO_HUMAN PTPRO_HUMAN]] Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).<ref>PMID:19167335</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018058037</ref><references group="xtra"/> | <ref group="xtra">PMID:018058037</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein-tyrosine-phosphatase]] | [[Category: Protein-tyrosine-phosphatase]] | ||
