3lgf: Difference between revisions
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{{STRUCTURE_3lgf| PDB=3lgf | SCENE= }} | {{STRUCTURE_3lgf| PDB=3lgf | SCENE= }} | ||
===Crystal structure of the 53BP1 tandem tudor domain in complex with p53K370me2=== | ===Crystal structure of the 53BP1 tandem tudor domain in complex with p53K370me2=== | ||
{{ABSTRACT_PUBMED_20307547}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref><ref>PMID:17190600</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3lgf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LGF OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020307547</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Kutateladze, T G.]] | [[Category: Kutateladze, T G.]] | ||
| Line 36: | Line 26: | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||