2d82: Difference between revisions

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~~[[Image:2d82.png|left|200px]]~~

===Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association===

===~~Target Structure~~-~~Based Discovery~~ of ~~Small Molecules that Block Human p53 and CREB Binding Protein~~ (~~CBP~~) ~~Association===~~

==Disease==

[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[http://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref><ref>PMID:12114483</ref><ref>PMID:12566391</ref><ref>PMID:15706485</ref>

~~{{ABSTRACT_PUBMED_16426974}}~~

==Function==

[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref><ref>PMID:11154691</ref><ref>PMID:12738767</ref><ref>PMID:12929931</ref>

==About this Structure==

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==Reference==

[[Category: Histone acetyltransferase]]

[[Category: Homo sapiens]]

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@@ Line 1: / Line 1: @@
-[[Image:2d82.png|left|200px]]
 {{STRUCTURE_2d82|  PDB=2d82  |  SCENE=  }}
+===Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association===
+{{ABSTRACT_PUBMED_16426974}}
-===Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association===
+==Disease==
+[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.  Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[http://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref><ref>PMID:12114483</ref><ref>PMID:12566391</ref><ref>PMID:15706485</ref>
-{{ABSTRACT_PUBMED_16426974}}
+==Function==
+[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref><ref>PMID:11154691</ref><ref>PMID:12738767</ref><ref>PMID:12929931</ref>
 ==About this Structure==
@@ Line 11: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:016426974</ref><references group="xtra"/>
+<ref group="xtra">PMID:016426974</ref><references group="xtra"/><references/>
 [[Category: Histone acetyltransferase]]
 [[Category: Homo sapiens]]