2wvr: Difference between revisions

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~~[[Image:2wvr.png|left|200px]]~~

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~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~

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===HUMAN CDT1:GEMININ COMPLEX===

==Disease==

[[http://www.uniprot.org/uniprot/CDT1_HUMAN CDT1_HUMAN]] Defects in CDT1 are the cause of Meier-Gorlin syndrome type 4 (MGORS4) [MIM:[http://omim.org/entry/613804 613804]]. MGORS4 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.<ref>PMID:21358632</ref><ref>PMID:21358631</ref>

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==Function==

~~The line below this paragraph, {{ABSTRACT_PUBMED_19906994}}, adds~~ the ~~Publication Abstract to~~ the ~~page~~

[[http://www.uniprot.org/uniprot/GEMI_HUMAN GEMI_HUMAN]] Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.<ref>PMID:9635433</ref><ref>PMID:14993212</ref><ref>PMID:22615398</ref> Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.<ref>PMID:9635433</ref><ref>PMID:14993212</ref><ref>PMID:22615398</ref> [[http://www.uniprot.org/uniprot/CDT1_HUMAN CDT1_HUMAN]] Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene.<ref>PMID:11125146</ref><ref>PMID:21856198</ref><ref>PMID:14672932</ref><ref>PMID:14993212</ref>[UniProtKB:Q8R4E9]

~~(as it appears on PubMed~~ at http://www.~~pubmed~~.~~gov), where 19906994 is~~ the ~~PubMed ID number~~.

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~~{{ABSTRACT_PUBMED_19906994}}~~

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Marco, V De.]]

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@@ Line 1: / Line 1: @@
-[[Image:2wvr.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_2wvr", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_2wvr|  PDB=2wvr  |  SCENE=  }}
 ===HUMAN CDT1:GEMININ COMPLEX===
+{{ABSTRACT_PUBMED_19906994}}
+==Disease==
+[[http://www.uniprot.org/uniprot/CDT1_HUMAN CDT1_HUMAN]] Defects in CDT1 are the cause of Meier-Gorlin syndrome type 4 (MGORS4) [MIM:[http://omim.org/entry/613804 613804]]. MGORS4 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.<ref>PMID:21358632</ref><ref>PMID:21358631</ref>
-<!--
+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_19906994}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/GEMI_HUMAN GEMI_HUMAN]] Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.<ref>PMID:9635433</ref><ref>PMID:14993212</ref><ref>PMID:22615398</ref>  Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.<ref>PMID:9635433</ref><ref>PMID:14993212</ref><ref>PMID:22615398</ref> [[http://www.uniprot.org/uniprot/CDT1_HUMAN CDT1_HUMAN]] Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene.<ref>PMID:11125146</ref><ref>PMID:21856198</ref><ref>PMID:14672932</ref><ref>PMID:14993212</ref>[UniProtKB:Q8R4E9]
-(as it appears on PubMed at http://www.pubmed.gov), where 19906994 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_19906994}}
 ==About this Structure==
@@ Line 22: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:019906994</ref><references group="xtra"/>
+<ref group="xtra">PMID:019906994</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Marco, V De.]]