3ry6: Difference between revisions

Line 1:

~~[[Image:3ry6.png|left|200px]]~~

~~<!--~~

~~The line below this paragraph, containing "STRUCTURE_3ry6", creates the "Structure Box" on the page.~~

~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~

~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~

~~or leave the SCENE parameter empty for the default display.~~

~~-->~~

===Complex of fcgammariia (CD32) and the FC of human IGG1===

==Disease==

[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

~~<!--~~

==Function==

~~The line below this paragraph, {{ABSTRACT_PUBMED_21856937}}, adds the Publication Abstract to the page~~

[[http://www.uniprot.org/uniprot/FCG2A_HUMAN FCG2A_HUMAN]] Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.<ref>PMID:19011614</ref>

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 21856937 is~~ the ~~PubMed ID number~~.

-->

~~{{ABSTRACT_PUBMED_21856937}}~~

==About this Structure==

Line 22:

Line 13:

==Reference==

[[Category: Homo sapiens]]

[[Category: Farrugia, W.]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:3ry6.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3ry6", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3ry6|  PDB=3ry6  |  SCENE=  }}
 ===Complex of fcgammariia (CD32) and the FC of human IGG1===
+{{ABSTRACT_PUBMED_21856937}}
+==Disease==
+[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
-<!--
+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_21856937}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/FCG2A_HUMAN FCG2A_HUMAN]] Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.<ref>PMID:19011614</ref>
-(as it appears on PubMed at http://www.pubmed.gov), where 21856937 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_21856937}}
 ==About this Structure==
@@ Line 22: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:021856937</ref><references group="xtra"/>
+<ref group="xtra">PMID:021856937</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Farrugia, W.]]