2vfa: Difference between revisions
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{{STRUCTURE_2vfa| PDB=2vfa | SCENE= }} | {{STRUCTURE_2vfa| PDB=2vfa | SCENE= }} | ||
===Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases=== | ===Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases=== | ||
{{ABSTRACT_PUBMED_18536021}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HGXR_PLAFG HGXR_PLAFG]] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, hypoxanthine and xanthine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. | |||
==About this Structure== | ==About this Structure== | ||
[[2vfa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum | [[2vfa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFA OCA]. | ||
==See Also== | |||
*[[Phosphoribosyltransferase|Phosphoribosyltransferase]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018536021</ref><references group="xtra"/> | <ref group="xtra">PMID:018536021</ref><references group="xtra"/><references/> | ||
[[Category: Plasmodium falciparum | [[Category: Plasmodium falciparum]] | ||
[[Category: Ashok, C S.]] | [[Category: Ashok, C S.]] | ||
[[Category: Balaram, H.]] | [[Category: Balaram, H.]] | ||
Revision as of 04:09, 25 March 2013
Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases
Template:ABSTRACT PUBMED 18536021
Function
[HGXR_PLAFG] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, hypoxanthine and xanthine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
About this Structure
2vfa is a 2 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.
See Also
Reference
- Gayathri P, Sujay Subbayya IN, Ashok CS, Selvi TS, Balaram H, Murthy MR. Crystal structure of a chimera of human and Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferases provides insights into oligomerization. Proteins. 2008 Dec;73(4):1010-20. PMID:18536021 doi:10.1002/prot.22129
