1iv5: Difference between revisions
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{{STRUCTURE_1iv5| PDB=1iv5 | SCENE= }} | {{STRUCTURE_1iv5| PDB=1iv5 | SCENE= }} | ||
===New Crystal Form of Human CD81 Large Extracellular Loop.=== | |||
{{ABSTRACT_PUBMED_12437138}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:[http://omim.org/entry/613496 613496]]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20237408</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012437138</ref><references group="xtra"/> | <ref group="xtra">PMID:012437138</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bolognesi, M.]] | [[Category: Bolognesi, M.]] | ||
