3iu3: Difference between revisions
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{{STRUCTURE_3iu3| PDB=3iu3 | SCENE= }} | {{STRUCTURE_3iu3| PDB=3iu3 | SCENE= }} | ||
===Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain=== | |||
{{ABSTRACT_PUBMED_20032294}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/IL2RA_HUMAN IL2RA_HUMAN]] Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:[http://omim.org/entry/601942 601942]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:17676041</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IL2RA_HUMAN IL2RA_HUMAN]] Receptor for interleukin-2. | |||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[Interleukin receptor|Interleukin receptor]] | *[[Interleukin receptor|Interleukin receptor]] | ||
*[[Monoclonal Antibody|Monoclonal Antibody]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020032294</ref><references group="xtra"/> | <ref group="xtra">PMID:020032294</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ding, J.]] | [[Category: Ding, J.]] | ||
