2lqh: Difference between revisions
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{{STRUCTURE_2lqh| PDB=2lqh | SCENE= }} | {{STRUCTURE_2lqh| PDB=2lqh | SCENE= }} | ||
===NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2b3l conformation)=== | ===NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2b3l conformation)=== | ||
{{ABSTRACT_PUBMED_22474372}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CBP_MOUSE CBP_MOUSE]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).<ref>PMID:10207073</ref><ref>PMID:11701890</ref><ref>PMID:15220471</ref><ref>PMID:16287980</ref> | |||
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:022474372</ref><references group="xtra"/> | <ref group="xtra">PMID:022474372</ref><references group="xtra"/><references/> | ||
[[Category: Histone acetyltransferase]] | [[Category: Histone acetyltransferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||