3h7d: Difference between revisions
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{{STRUCTURE_3h7d| PDB=3h7d | SCENE= }} | {{STRUCTURE_3h7d| PDB=3h7d | SCENE= }} | ||
===The crystal structure of the cathepsin K Variant M5 in complex with chondroitin-4-sulfate=== | |||
{{ABSTRACT_PUBMED_021193413}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref><ref>PMID:9529353</ref><ref>PMID:10491211</ref><ref>PMID:10878663</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021193413</ref><references group="xtra"/> | <ref group="xtra">PMID:021193413</ref><references group="xtra"/><references/> | ||
[[Category: Cathepsin K]] | [[Category: Cathepsin K]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
