2d9q: Difference between revisions
New page: left|200px<br /> <applet load="2d9q" size="450" color="white" frame="true" align="right" spinBox="true" caption="2d9q, resolution 2.80Å" /> '''Crystal Structure o... |
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[[Image:2d9q.gif|left|200px]]<br /> | [[Image:2d9q.gif|left|200px]]<br /><applet load="2d9q" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''Crystal Structure of the Human GCSF-Receptor Signaling Complex'''<br /> | '''Crystal Structure of the Human GCSF-Receptor Signaling Complex'''<br /> | ||
==Overview== | ==Overview== | ||
A crystal structure of the signaling complex between human granulocyte | A crystal structure of the signaling complex between human granulocyte colony-stimulating factor (GCSF) and a ligand binding region of GCSF receptor (GCSF-R), has been determined to 2.8 A resolution. The GCSF:GCSF-R complex formed a 2:2 stoichiometry by means of a cross-over interaction between the Ig-like domains of GCSF-R and GCSF. The conformation of the complex is quite different from that between human GCSF and the cytokine receptor homologous domain of mouse GCSF-R, but similar to that of the IL-6/gp130 signaling complex. The Ig-like domain cross-over structure necessary for GCSF-R activation is consistent with previously reported thermodynamic and mutational analyses. | ||
==About this Structure== | ==About this Structure== | ||
2D9Q is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 2D9Q is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9Q OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: ligand-receptor complex]] | [[Category: ligand-receptor complex]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:56:32 2008'' | ||
Revision as of 14:56, 21 February 2008
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Crystal Structure of the Human GCSF-Receptor Signaling Complex
Overview
A crystal structure of the signaling complex between human granulocyte colony-stimulating factor (GCSF) and a ligand binding region of GCSF receptor (GCSF-R), has been determined to 2.8 A resolution. The GCSF:GCSF-R complex formed a 2:2 stoichiometry by means of a cross-over interaction between the Ig-like domains of GCSF-R and GCSF. The conformation of the complex is quite different from that between human GCSF and the cytokine receptor homologous domain of mouse GCSF-R, but similar to that of the IL-6/gp130 signaling complex. The Ig-like domain cross-over structure necessary for GCSF-R activation is consistent with previously reported thermodynamic and mutational analyses.
About this Structure
2D9Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex., Tamada T, Honjo E, Maeda Y, Okamoto T, Ishibashi M, Tokunaga M, Kuroki R, Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3135-40. Epub 2006 Feb 21. PMID:16492764
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