3a2i: Difference between revisions

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{{Seed}}
[[Image:3a2i.png|left|200px]]
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{{STRUCTURE_3a2i|  PDB=3a2i  |  SCENE=  }}  
{{STRUCTURE_3a2i|  PDB=3a2i  |  SCENE=  }}  
===Crystal structure of the human vitamin D receptor (H305F) ligand binding domain complexed with TEI-9647===
===Crystal structure of the human vitamin D receptor (H305F) ligand binding domain complexed with TEI-9647===
{{ABSTRACT_PUBMED_20693691}}


==Disease==
[[http://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:[http://omim.org/entry/277440 277440]]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.<ref>PMID:2849209</ref><ref>PMID:8381803</ref><ref>PMID:1652893</ref><ref>PMID:2177843</ref><ref>PMID:8106618</ref><ref>PMID:8392085</ref><ref>PMID:7828346</ref><ref>PMID:8675579</ref><ref>PMID:8961271</ref><ref>PMID:9005998</ref>


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_20693691}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:16252006</ref><ref>PMID:10678179</ref><ref>PMID:15728261</ref><ref>PMID:16913708</ref>  
(as it appears on PubMed at http://www.pubmed.gov), where 20693691 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20693691}}


==About this Structure==
==About this Structure==
3A2I is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A2I OCA].  
[[3a2i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A2I OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20693691</ref><references group="xtra"/>
<ref group="xtra">PMID:020693691</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kakuda, S.]]
[[Category: Kakuda, S.]]
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[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:09:50 2010''
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