1pr9: Difference between revisions
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{{STRUCTURE_1pr9| PDB=1pr9 | SCENE= }} | {{STRUCTURE_1pr9| PDB=1pr9 | SCENE= }} | ||
===Human L-Xylulose Reductase Holoenzyme=== | |||
{{ABSTRACT_PUBMED_15103634}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/DCXR_HUMAN DCXR_HUMAN]] Note=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DCXR_HUMAN DCXR_HUMAN]] Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:015103634</ref><ref group="xtra">PMID:012136162</ref><references group="xtra"/> | <ref group="xtra">PMID:015103634</ref><ref group="xtra">PMID:012136162</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: L-xylulose reductase]] | [[Category: L-xylulose reductase]] | ||
