3qbq: Difference between revisions

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[[Image:3qbq.jpg|left|200px]]
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{{STRUCTURE_3qbq|  PDB=3qbq  |  SCENE=  }}  
{{STRUCTURE_3qbq|  PDB=3qbq  |  SCENE=  }}  
===Crystal structure of extracellular domains of mouse RANK-RANKL complex===
===Crystal structure of extracellular domains of mouse RANK-RANKL complex===
{{ABSTRACT_PUBMED_21059944}}


==Disease==
[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Note=Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_21059944}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/TNF11_MOUSE TNF11_MOUSE]] Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. [[http://www.uniprot.org/uniprot/TNR11_MOUSE TNR11_MOUSE]] Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.<ref>PMID:9878548</ref><ref>PMID:20483727</ref>  
(as it appears on PubMed at http://www.pubmed.gov), where 21059944 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21059944}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:21059944</ref><references group="xtra"/>
<ref group="xtra">PMID:021059944</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Choi, J K.]]
[[Category: Choi, J K.]]
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[[Category: Park, H.]]
[[Category: Park, H.]]
[[Category: Ta, H M.]]
[[Category: Ta, H M.]]
[[Category: Cytokine-cytokine receptor complex]]
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