6fit: Difference between revisions

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{{Seed}}
[[Image:6fit.png|left|200px]]
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{{STRUCTURE_6fit|  PDB=6fit  |  SCENE=  }}  
{{STRUCTURE_6fit|  PDB=6fit  |  SCENE=  }}  
===FHIT-TRANSITION STATE ANALOG===
===FHIT-TRANSITION STATE ANALOG===
{{ABSTRACT_PUBMED_9323207}}


==Disease==
[[http://www.uniprot.org/uniprot/FHIT_HUMAN FHIT_HUMAN]] Note=A chromosomal aberration involving FHIT has been found in a lymphoblastoid cell line established from a family with renal cell carcinoma and thyroid carcinoma. Translocation t(3;8)(p14.2;q24.1) with RNF139. Although the 3p14.2 breakpoint has been shown to interrupt FHIT in its 5-prime non-coding region, it is unlikely that FHIT is causally related to renal or other malignancies.<ref>PMID:15007172</ref>  Note=Associated with digestive tract cancers. Numerous tumor types are found to have aberrant forms of FHIT protein due to deletions in a coding region of chromosome 3p14.2 including the fragile site locus FRA3B.<ref>PMID:15007172</ref>


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_9323207}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/FHIT_HUMAN FHIT_HUMAN]] Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues.<ref>PMID:8794732</ref>  
(as it appears on PubMed at http://www.pubmed.gov), where 9323207 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9323207}}


==About this Structure==
==About this Structure==
6FIT is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FIT OCA].  
[[6fit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FIT OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:9323207</ref><references group="xtra"/>
<ref group="xtra">PMID:009323207</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hendrickson, W A.]]
[[Category: Hendrickson, W A.]]
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[[Category: Nucleotidyl transferase]]
[[Category: Nucleotidyl transferase]]
[[Category: Putative tumor suppressor]]
[[Category: Putative tumor suppressor]]
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Retrieved from "https://proteopedia.org/6fit"