4fa8: Difference between revisions
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{{STRUCTURE_4fa8| PDB=4fa8 | SCENE= }} | {{STRUCTURE_4fa8| PDB=4fa8 | SCENE= }} | ||
===Multi-pronged modulation of cytokine signaling=== | |||
{{ABSTRACT_PUBMED_22826234}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CSF1_HUMAN CSF1_HUMAN]] Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.<ref>PMID:16337366</ref><ref>PMID:19934330</ref> Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.<ref>PMID:16337366</ref><ref>PMID:19934330</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BARF1_EBVG BARF1_EBVG]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro (By similarity). [[http://www.uniprot.org/uniprot/CSF1_HUMAN CSF1_HUMAN]] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.<ref>PMID:16337366</ref><ref>PMID:19934330</ref><ref>PMID:20829061</ref><ref>PMID:20504948</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:022826234</ref><references group="xtra"/> | <ref group="xtra">PMID:022826234</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Human herpesvirus 4]] | [[Category: Human herpesvirus 4]] | ||
