2wy3: Difference between revisions
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{{STRUCTURE_2wy3| PDB=2wy3 | SCENE= }} | {{STRUCTURE_2wy3| PDB=2wy3 | SCENE= }} | ||
===STRUCTURE OF THE HCMV UL16-MICB COMPLEX ELUCIDATES SELECT BINDING OF A VIRAL IMMUNOEVASIN TO DIVERSE NKG2D LIGANDS=== | ===STRUCTURE OF THE HCMV UL16-MICB COMPLEX ELUCIDATES SELECT BINDING OF A VIRAL IMMUNOEVASIN TO DIVERSE NKG2D LIGANDS=== | ||
{{ABSTRACT_PUBMED_20090832}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/UL16P_HCMVA UL16P_HCMVA]] Plays a role in escape from host immune response. Blocks the interaction between the host NKG2D receptor with the ligands ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. The sequestration of diverse NKG2D ligands in the endoplasmic reticulum and cis-Golgi apparatus of cells by UL16 inhibits the activation of NK cells.<ref>PMID:12847260</ref><ref>PMID:12782710</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020090832</ref><references group="xtra"/> | <ref group="xtra">PMID:020090832</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Human herpesvirus 5 strain ad169]] | [[Category: Human herpesvirus 5 strain ad169]] | ||
