2dde: Difference between revisions

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[[Image:2dde.gif|left|200px]]<br /><applet load="2dde" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:2dde.gif|left|200px]]<br /><applet load="2dde" size="350" color="white" frame="true" align="right" spinBox="true"

caption="2dde" />

'''Structure of cinnamycin complexed with lysophosphatidylethanolamine'''<br />

==Overview==

The three-dimensional structure of a complex of cinnamycin, a 19-amino, acid residue immunopotentiator peptide, and lysophosphatidylethanolamine, was determined by 1H-NMR. The complex was cylindrical in shape, 11 A in, diameter and 26 A in length, excluding the acyl chain of the phospholipid., The peptide had a hydrophobic pocket surrounded by residues Phe-7 through, Ala(S)-14 to bind to the head group of the ligand. Fitting of the head, group to the hydrophobic pocket was so good that other than a, glycerophosphoethanolamine head group would be unable to fit the pocket., The goodness of the fitting is compatible with the strict specificity of, ligand binding of the peptide.

The three-dimensional structure of a complex of cinnamycin, a 19-amino acid residue immunopotentiator peptide, and lysophosphatidylethanolamine was determined by 1H-NMR. The complex was cylindrical in shape, 11 A in diameter and 26 A in length, excluding the acyl chain of the phospholipid. The peptide had a hydrophobic pocket surrounded by residues Phe-7 through Ala(S)-14 to bind to the head group of the ligand. Fitting of the head group to the hydrophobic pocket was so good that other than a glycerophosphoethanolamine head group would be unable to fit the pocket. The goodness of the fitting is compatible with the strict specificity of ligand binding of the peptide.

==About this Structure==

2DDE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_griseoverticillatus Streptomyces griseoverticillatus] with LSP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2DDE OCA].

2DDE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_griseoverticillatus Streptomyces griseoverticillatus] with <scene name='pdbligand=LSP:'>LSP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDE OCA].

==Reference==

Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1., Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K, J Biochem ~~(Tokyo)~~. 1996 Feb;119(2):226-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8882709 8882709]

Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1., Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K, J Biochem. 1996 Feb;119(2):226-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8882709 8882709]

[[Category: Single protein]]

[[Category: Streptomyces griseoverticillatus]]

Line 25:

[[Category: phosphatidylethanolamine]]

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@@ Line 1: / Line 1: @@
-[[Image:2dde.gif|left|200px]]<br /><applet load="2dde" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:2dde.gif|left|200px]]<br /><applet load="2dde" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="2dde" />
 '''Structure of cinnamycin complexed with lysophosphatidylethanolamine'''<br />
 ==Overview==
-The three-dimensional structure of a complex of cinnamycin, a 19-amino, acid residue immunopotentiator peptide, and lysophosphatidylethanolamine, was determined by 1H-NMR. The complex was cylindrical in shape, 11 A in, diameter and 26 A in length, excluding the acyl chain of the phospholipid., The peptide had a hydrophobic pocket surrounded by residues Phe-7 through, Ala(S)-14 to bind to the head group of the ligand. Fitting of the head, group to the hydrophobic pocket was so good that other than a, glycerophosphoethanolamine head group would be unable to fit the pocket., The goodness of the fitting is compatible with the strict specificity of, ligand binding of the peptide.
+The three-dimensional structure of a complex of cinnamycin, a 19-amino acid residue immunopotentiator peptide, and lysophosphatidylethanolamine was determined by 1H-NMR. The complex was cylindrical in shape, 11 A in diameter and 26 A in length, excluding the acyl chain of the phospholipid. The peptide had a hydrophobic pocket surrounded by residues Phe-7 through Ala(S)-14 to bind to the head group of the ligand. Fitting of the head group to the hydrophobic pocket was so good that other than a glycerophosphoethanolamine head group would be unable to fit the pocket. The goodness of the fitting is compatible with the strict specificity of ligand binding of the peptide.
 ==About this Structure==
-DDE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_griseoverticillatus Streptomyces griseoverticillatus] with LSP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DDE OCA].
+DDE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_griseoverticillatus Streptomyces griseoverticillatus] with <scene name='pdbligand=LSP:'>LSP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDE OCA].
 ==Reference==
-Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1., Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K, J Biochem (Tokyo). 1996 Feb;119(2):226-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8882709 8882709]
+Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1., Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K, J Biochem. 1996 Feb;119(2):226-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8882709 8882709]
 [[Category: Single protein]]
 [[Category: Streptomyces griseoverticillatus]]
@@ Line 25: / Line 25: @@
 [[Category: phosphatidylethanolamine]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 09:33:05 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:57:39 2008''