3nj4: Difference between revisions

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[[Image:3nj4.jpg|left|200px]]
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{{STRUCTURE_3nj4|  PDB=3nj4  |  SCENE=  }}  
{{STRUCTURE_3nj4|  PDB=3nj4  |  SCENE=  }}  
===Fluoro-neplanocin A in Human S-Adenosylhomocysteine Hydrolase===
===Fluoro-neplanocin A in Human S-Adenosylhomocysteine Hydrolase===
{{ABSTRACT_PUBMED_21226494}}


==Disease==
[[http://www.uniprot.org/uniprot/SAHH_HUMAN SAHH_HUMAN]] Defects in AHCY are the cause of hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) [MIM:[http://omim.org/entry/613752 613752]]. A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy.<ref>PMID:15024124</ref><ref>PMID:16736098</ref><ref>PMID:19177456</ref><ref>PMID:20852937</ref>


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_21226494}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/SAHH_HUMAN SAHH_HUMAN]] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.<ref>PMID:12590576</ref>  
(as it appears on PubMed at http://www.pubmed.gov), where 21226494 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21226494}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:021226494</ref><references group="xtra"/>
<ref group="xtra">PMID:021226494</ref><references group="xtra"/><references/>
[[Category: Adenosylhomocysteinase]]
[[Category: Adenosylhomocysteinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Jeong, L S.]]
[[Category: Jeong, L S.]]
[[Category: Lee, K M.]]
[[Category: Lee, K M.]]
[[Category: Hydrolase]]
[[Category: Nad]]
[[Category: S-adenosylhomocystein]]
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