2lv6: Difference between revisions

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~~[[Image:2lv6.jpg|left|200px]]~~

===The complex between Ca-Calmodulin and skeletal muscle myosin light chain kinase from combination of NMR and aqueous and contrast-matched SAXS data===

===The ~~complex between Ca~~-~~Calmodulin~~ and ~~skeletal muscle myosin light chain kinase~~ from ~~combination~~ of ~~NMR and aqueous~~ and ~~contrast-matched SAXS data===~~

==Disease==

[[http://www.uniprot.org/uniprot/MYLK2_HUMAN MYLK2_HUMAN]] Familial isolated hypertrophic cardiomyopathy. Defects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:[http://omim.org/entry/192600 192600]]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:11733062</ref>

~~{{ABSTRACT_PUBMED_22908850}}~~

==Function==

[[http://www.uniprot.org/uniprot/MYLK2_HUMAN MYLK2_HUMAN]] Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.<ref>PMID:11733062</ref>

==About this Structure==

[[2lv6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LV6 OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Anthis, N J.]]

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@@ Line 1: / Line 1: @@
-[[Image:2lv6.jpg|left|200px]]
 {{STRUCTURE_2lv6|  PDB=2lv6  |  SCENE=  }}
+===The complex between Ca-Calmodulin and skeletal muscle myosin light chain kinase from combination of NMR and aqueous and contrast-matched SAXS data===
+{{ABSTRACT_PUBMED_22908850}}
-===The complex between Ca-Calmodulin and skeletal muscle myosin light chain kinase from combination of NMR and aqueous and contrast-matched SAXS data===
+==Disease==
+[[http://www.uniprot.org/uniprot/MYLK2_HUMAN MYLK2_HUMAN]] Familial isolated hypertrophic cardiomyopathy. Defects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:[http://omim.org/entry/192600 192600]]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:11733062</ref>
-{{ABSTRACT_PUBMED_22908850}}
+==Function==
+[[http://www.uniprot.org/uniprot/MYLK2_HUMAN MYLK2_HUMAN]] Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.<ref>PMID:11733062</ref>
 ==About this Structure==
 [[2lv6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LV6 OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Anthis, N J.]]