3zxo: Difference between revisions
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{{STRUCTURE_3zxo| PDB=3zxo | SCENE= }} | {{STRUCTURE_3zxo| PDB=3zxo | SCENE= }} | ||
===CRYSTAL STRUCTURE OF THE MUTANT ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOSS=== | ===CRYSTAL STRUCTURE OF THE MUTANT ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOSS=== | ||
{{ABSTRACT_PUBMED_23486471}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DEVS_MYCTU DEVS_MYCTU]] Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaerobic growth) Fe(2+) form is probably active for phosphate transfer. It is probably reduced by flavin nucleotides such as FMN and FAD. May be the primary sensor for CO. Donates a phosphate group to DevR (DosR).<ref>PMID:15033981</ref><ref>PMID:18474359</ref><ref>PMID:18400743</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3zxo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3zxo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXO OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:016213520</ref><references group="xtra"/> | <ref group="xtra">PMID:016213520</ref><references group="xtra"/><references/> | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis h37rv]] | ||
[[Category: Cho, H J.]] | [[Category: Cho, H J.]] | ||
[[Category: Cho, H Y.]] | [[Category: Cho, H Y.]] | ||
[[Category: Kang, B S.]] | [[Category: Kang, B S.]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 07:48, 27 March 2013
CRYSTAL STRUCTURE OF THE MUTANT ATP-BINDING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS DOSS
Template:ABSTRACT PUBMED 23486471
Function
[DEVS_MYCTU] Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaerobic growth) Fe(2+) form is probably active for phosphate transfer. It is probably reduced by flavin nucleotides such as FMN and FAD. May be the primary sensor for CO. Donates a phosphate group to DevR (DosR).[1][2][3]
About this Structure
3zxo is a 2 chain structure with sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.
Reference
- Sardiwal S, Kendall SL, Movahedzadeh F, Rison SC, Stoker NG, Djordjevic S. A GAF domain in the hypoxia/NO-inducible Mycobacterium tuberculosis DosS protein binds haem. J Mol Biol. 2005 Nov 11;353(5):929-36. Epub 2005 Sep 27. PMID:16213520 doi:10.1016/j.jmb.2005.09.011
- ↑ Roberts DM, Liao RP, Wisedchaisri G, Hol WG, Sherman DR. Two sensor kinases contribute to the hypoxic response of Mycobacterium tuberculosis. J Biol Chem. 2004 May 28;279(22):23082-7. Epub 2004 Mar 19. PMID:15033981 doi:10.1074/jbc.M401230200
- ↑ Shiloh MU, Manzanillo P, Cox JS. Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection. Cell Host Microbe. 2008 May 15;3(5):323-30. doi: 10.1016/j.chom.2008.03.007. PMID:18474359 doi:10.1016/j.chom.2008.03.007
- ↑ Kumar A, Deshane JS, Crossman DK, Bolisetty S, Yan BS, Kramnik I, Agarwal A, Steyn AJ. Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon. J Biol Chem. 2008 Jun 27;283(26):18032-9. doi: 10.1074/jbc.M802274200. Epub 2008 , Apr 9. PMID:18400743 doi:10.1074/jbc.M802274200
