4fdg: Difference between revisions
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{{STRUCTURE_4fdg| PDB=4fdg | SCENE= }} | {{STRUCTURE_4fdg| PDB=4fdg | SCENE= }} | ||
===Crystal Structure of an Archaeal MCM Filament=== | |||
{{ABSTRACT_PUBMED_23361460}} | |||
== | ==Function== | ||
[[http://www.uniprot.org/uniprot/MCM_SULSO MCM_SULSO]] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4fdg]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FDG OCA]. | [[4fdg]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FDG OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: DNA helicase]] | [[Category: DNA helicase]] | ||
[[Category: Sulfolobus solfataricus]] | [[Category: Sulfolobus solfataricus]] | ||
