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===Crystal structure of the G202A mutant of human G-alpha-i1=== | ===Crystal structure of the G202A mutant of human G-alpha-i1=== | ||
{{ABSTRACT_PUBMED_20351284}} | {{ABSTRACT_PUBMED_20351284}} | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref><ref>PMID:17264214</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020351284</ref><references group="xtra"/> | <ref group="xtra">PMID:020351284</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Cappell, S D.]] | [[Category: Cappell, S D.]] | ||
