1n5d: Difference between revisions
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===CRYSTAL STRUCTURE OF PORCINE TESTICULAR CARBONYL REDUCTASE/ 20BETA-HYDROXYSTEROID DEHYDROGENASE=== | ===CRYSTAL STRUCTURE OF PORCINE TESTICULAR CARBONYL REDUCTASE/ 20BETA-HYDROXYSTEROID DEHYDROGENASE=== | ||
{{ABSTRACT_PUBMED_11279087}} | {{ABSTRACT_PUBMED_11279087}} | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/CBR1_PIG CBR1_PIG]] NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity).<ref>PMID:1377683</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:011279087</ref><ref group="xtra">PMID:015799708</ref><references group="xtra"/> | <ref group="xtra">PMID:011279087</ref><ref group="xtra">PMID:015799708</ref><references group="xtra"/><references/> | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
[[Category: Ghosh, D.]] | [[Category: Ghosh, D.]] | ||
