4dw6: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Novel N-phenyl-phenoxyacetamide derivatives as potential EthR inhibitors and ethionamide boosters. Discovery and optimization using High-Throughput Synthesis.===

~~The entry 4dw6~~ is ~~ON HOLD until Mar 27 2014~~

==Function==

[[http://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref><ref>PMID:10944230</ref>

~~Authors~~: ~~Flipo, M~~.~~, Willand, N~~.~~, Lecat-Guillet, N~~.~~, Hounsou, C~~.~~, Desroses, M~~.~~, Leroux, F~~.~~, Lens, Z., Villeret, V., Wohlkonig, A., Wintjens, R., Christophe, T., Jeon, H.K., Locht, C., Brodin, P., Baulard, A.R., Deprez, B~~.

==About this Structure==

[[4dw6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DW6 OCA].

~~Description~~: ~~Novel~~ N-~~phenyl~~-~~phenoxyacetamide derivatives as potential EthR inhibitors and ethionamide boosters. Discovery and optimization using High~~-~~Throughput Synthesis.~~

==Reference==

[[Category: Mycobacterium tuberculosis]]

[[Category: Baulard, A R.]]

[[Category: Brodin, P.]]

[[Category: Christophe, T.]]

[[Category: Deprez, B.]]

[[Category: Desroses, M.]]

[[Category: Flipo, M.]]

[[Category: Hounsou, C.]]

[[Category: Jeon, H K.]]

[[Category: Lecat-Guillet, N.]]

[[Category: Lens, Z.]]

[[Category: Leroux, F.]]

[[Category: Locht, C.]]

[[Category: Villeret, V.]]

[[Category: Willand, N.]]

[[Category: Wintjens, R.]]

[[Category: Wohlkonig, A.]]

[[Category: Dna binding protein]]

[[Category: Inhibitor]]

[[Category: Tetr-family]]

[[Category: Transcription repressor-inhibitor complex]]

[[Category: Transcription-inhibitor complex]]

[[Category: Transcritptional regulatory repressor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4dw6|  PDB=4dw6  |  SCENE=  }}
+===Novel N-phenyl-phenoxyacetamide derivatives as potential EthR inhibitors and ethionamide boosters. Discovery and optimization using High-Throughput Synthesis.===
+{{ABSTRACT_PUBMED_022738293}}
-The entry 4dw6 is ON HOLD  until Mar 27 2014
+==Function==
+[[http://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref><ref>PMID:10944230</ref>
-Authors: Flipo, M., Willand, N., Lecat-Guillet, N., Hounsou, C., Desroses, M., Leroux, F., Lens, Z., Villeret, V., Wohlkonig, A., Wintjens, R., Christophe, T., Jeon, H.K., Locht, C., Brodin, P., Baulard, A.R., Deprez, B.
+==About this Structure==
+[[4dw6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DW6 OCA].
-Description: Novel N-phenyl-phenoxyacetamide derivatives as potential EthR inhibitors and ethionamide boosters. Discovery and optimization using High-Throughput Synthesis.
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Mycobacterium tuberculosis]]
+[[Category: Baulard, A R.]]
+[[Category: Brodin, P.]]
+[[Category: Christophe, T.]]
+[[Category: Deprez, B.]]
+[[Category: Desroses, M.]]
+[[Category: Flipo, M.]]
+[[Category: Hounsou, C.]]
+[[Category: Jeon, H K.]]
+[[Category: Lecat-Guillet, N.]]
+[[Category: Lens, Z.]]
+[[Category: Leroux, F.]]
+[[Category: Locht, C.]]
+[[Category: Villeret, V.]]
+[[Category: Willand, N.]]
+[[Category: Wintjens, R.]]
+[[Category: Wohlkonig, A.]]
+[[Category: Dna binding protein]]
+[[Category: Inhibitor]]
+[[Category: Tetr-family]]
+[[Category: Transcription repressor-inhibitor complex]]
+[[Category: Transcription-inhibitor complex]]
+[[Category: Transcritptional regulatory repressor]]