3iqo: Difference between revisions
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{{STRUCTURE_3iqo| PDB=3iqo | SCENE= }} | {{STRUCTURE_3iqo| PDB=3iqo | SCENE= }} | ||
===1.5 angstrom X-ray structure of bovine Ca(2+)-S100B=== | ===1.5 angstrom X-ray structure of bovine Ca(2+)-S100B=== | ||
{{ABSTRACT_PUBMED_20053360}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3iqo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IQO OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020053360</ref><references group="xtra"/><references/> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Charpentier, T H.]] | [[Category: Charpentier, T H.]] | ||
[[Category: Toth, E A.]] | [[Category: Toth, E A.]] | ||
[[Category: Weber, D J.]] | [[Category: Weber, D J.]] | ||
[[Category: Alpha helical]] | [[Category: Alpha helical]] | ||
[[Category: Ef hand]] | [[Category: Ef hand]] | ||
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
[[Category: Nucleus]] | [[Category: Nucleus]] | ||