3izo: Difference between revisions

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[[Image:3izo.png|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3izo", creates the "Structure Box" on the page.
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{{STRUCTURE_3izo|  PDB=3izo  |  SCENE=  }}  
{{STRUCTURE_3izo|  PDB=3izo  |  SCENE=  }}  
===Model of the fiber tail and its interactions with the penton base of human adenovirus by cryo-electron microscopy===
===Model of the fiber tail and its interactions with the penton base of human adenovirus by cryo-electron microscopy===
{{ABSTRACT_PUBMED_21146538}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/PEN3_ADE05 PEN3_ADE05]] Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 verteces of the pseudo T=25 capsid. Involved in virus secondary attachment to host cell after initial attachment by the fiber protein. Binds host integrin heterodimer ITGAV-ITGB5 (alphaV-beta5) thereby triggering clathrin-mediated endocytosis of virions. Mediates initial virus attachment to CXADR-negative cells. Binding to integrins ITGAV-ITGB5 also seems to induce macropinocytosis uptake of the virus. As the virus enters the host cell, penton proteins are shedded concomitant with virion acidification in the endosome.<ref>PMID:20615244</ref><ref>PMID:20798312</ref>  
The line below this paragraph, {{ABSTRACT_PUBMED_21146538}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_21146538}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:21146538</ref><references group="xtra"/>
<ref group="xtra">PMID:021146538</ref><references group="xtra"/><references/>
[[Category: Human adenovirus 5]]
[[Category: Human adenovirus 5]]
[[Category: Liu, H.]]
[[Category: Liu, H.]]
[[Category: Human adenovirus fiber tail]]
[[Category: Pentameric penton base]]
[[Category: Trimeric fiber]]
[[Category: Viral protein]]
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