3jsk: Difference between revisions
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{{STRUCTURE_3jsk| PDB=3jsk | SCENE= }} | {{STRUCTURE_3jsk| PDB=3jsk | SCENE= }} | ||
===Thiazole synthase from Neurospora crassa=== | ===Thiazole synthase from Neurospora crassa=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/Q9HGR2_NEUCR Q9HGR2_NEUCR]] Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance (By similarity).<ref>PMID:15544818</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3jsk]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSK OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Neurospora crassa]] | [[Category: Neurospora crassa]] | ||
[[Category: Bale, S.]] | [[Category: Bale, S.]] | ||
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[[Category: Biosynthetic protein]] | [[Category: Biosynthetic protein]] | ||
[[Category: Octameric thiazole synthase]] | [[Category: Octameric thiazole synthase]] | ||