3iug: Difference between revisions

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===Crystal structure of the RhoGAP domain of RICS===

==Function==

[[http://www.uniprot.org/uniprot/RICS_HUMAN RICS_HUMAN]] GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).<ref>PMID:12446789</ref><ref>PMID:12819203</ref><ref>PMID:17663722</ref><ref>PMID:12788081</ref><ref>PMID:12454018</ref><ref>PMID:12531901</ref><ref>PMID:12857875</ref>

==About this Structure==

~~3IUG~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IUG OCA].

[[3iug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IUG OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Arrowsmith, C H.]]

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[[Category: Tong, Y.]]

[[Category: Weigelt, J.]]

~~[[Category: Alternative splicing]]~~

[[Category: Cell junction]]

[[Category: Cell membrane]]

[[Category: Cell projection]]

~~[[Category: Cytoplasm]]~~

[[Category: Endoplasmic reticulum]]

[[Category: Endosome]]

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[[Category: Postsynaptic cell membrane]]

[[Category: Sh3 domain]]

[[Category: Splicing]]

[[Category: Synapse]]

~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 09:31:39 2009''~~

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-{{Seed}}
-[[Image:3iug.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3iug", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3iug|  PDB=3iug  |  SCENE=  }}
 ===Crystal structure of the RhoGAP domain of RICS===
+==Function==
+[[http://www.uniprot.org/uniprot/RICS_HUMAN RICS_HUMAN]] GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).<ref>PMID:12446789</ref><ref>PMID:12819203</ref><ref>PMID:17663722</ref><ref>PMID:12788081</ref><ref>PMID:12454018</ref><ref>PMID:12531901</ref><ref>PMID:12857875</ref>
 ==About this Structure==
-IUG is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IUG OCA].
+[[3iug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IUG OCA].
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Arrowsmith, C H.]]
@@ Line 27: / Line 22: @@
 [[Category: Tong, Y.]]
 [[Category: Weigelt, J.]]
-[[Category: Alternative splicing]]
 [[Category: Cell junction]]
 [[Category: Cell membrane]]
 [[Category: Cell projection]]
-[[Category: Cytoplasm]]
 [[Category: Endoplasmic reticulum]]
 [[Category: Endosome]]
@@ Line 41: / Line 34: @@
 [[Category: Postsynaptic cell membrane]]
 [[Category: Sh3 domain]]
+[[Category: Splicing]]
 [[Category: Synapse]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 09:31:39 2009''