3ixe: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
{{Seed}}
[[Image:3ixe.png|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_3ixe", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet)
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_3ixe|  PDB=3ixe  |  SCENE=  }}  
{{STRUCTURE_3ixe|  PDB=3ixe  |  SCENE=  }}  
===Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase===
===Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase===
{{ABSTRACT_PUBMED_19963065}}


 
==Function==
<!--  
[[http://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN]] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. [[http://www.uniprot.org/uniprot/LIMS2_HUMAN LIMS2_HUMAN]] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.<ref>PMID:12167643</ref>  
The line below this paragraph, {{ABSTRACT_PUBMED_19963065}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 19963065 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_19963065}}


==About this Structure==
==About this Structure==
3IXE is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXE OCA].  
[[3ixe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXE OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:19963065</ref><references group="xtra"/>
<ref group="xtra">PMID:019963065</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
Line 30: Line 17:
[[Category: Chiswell, B P.]]
[[Category: Chiswell, B P.]]
[[Category: Stiegler, A L.]]
[[Category: Stiegler, A L.]]
[[Category: Alternative splicing]]
[[Category: Ank]]
[[Category: Ank]]
[[Category: Ank repeat]]
[[Category: Ank repeat]]
Line 53: Line 39:
[[Category: Signaling protein-signaling protein complex]]
[[Category: Signaling protein-signaling protein complex]]
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Zinc]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 31 12:47:36 2010''
Retrieved from "https://proteopedia.org/3ixe"