3hzi: Difference between revisions

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[[Image:3hzi.png|left|200px]]
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The line below this paragraph, containing "STRUCTURE_3hzi", creates the "Structure Box" on the page.
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{{STRUCTURE_3hzi|  PDB=3hzi  |  SCENE=  }}  
{{STRUCTURE_3hzi|  PDB=3hzi  |  SCENE=  }}  
===Structure of mdt protein===
===Structure of mdt protein===
{{ABSTRACT_PUBMED_19150849}}


 
==Function==
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[[http://www.uniprot.org/uniprot/HIPA_ECOLI HIPA_ECOLI]] Toxic component of a toxin-antitoxin (TA) module. Autophosphorylates (Ser-150) and phosphorylates EF-Tu in vitro (on 'Thr-383'), may act on other proteins as well. The hipA7 mutation leads to increased generation of persister cells, cells that survive antibiotic treatment probably by entering into a dormant state. Wild-type cells produce persisters at a frequency of 10-6 to 10-5 whereas mutant hipA7 cells produce persisters at a frequency of 10-2. Generation of persister cells requires (p)ppGpp as cells lacking relA or relA/spoT generate fewer or no persister cells respectively compared to hipA7. Low level expression of HipA causes cell filamentation and depending on the protein level is toxic enough to reduce cell growth or even kill cells. Expression of wild-type HipA also leads to high antibiotic tolerance of the survivor cells. The toxic effect of HipA is neutralized by its cognate antitoxin HipB. With HipB acts as a corepressor for transcription of the hipBA promoter.<ref>PMID:17041039</ref><ref>PMID:6348026</ref><ref>PMID:8021189</ref><ref>PMID:14622409</ref><ref>PMID:19150849</ref> [[http://www.uniprot.org/uniprot/HIPB_ECOLI HIPB_ECOLI]] Antitoxin component of a toxin-antitoxin (TA) module. Neutralizes the toxic effect of cognate toxin HipA. Binds to operator sites with the consensus sequence 5-'TATCCN(8)GGATA-3' to repress the hipBA operon promoter.
The line below this paragraph, {{ABSTRACT_PUBMED_19150849}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_19150849}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:019150849</ref><references group="xtra"/>
<ref group="xtra">PMID:019150849</ref><references group="xtra"/><references/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Schumacher, M A.]]
[[Category: Schumacher, M A.]]
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Transcription/dna complex]]
[[Category: Transcription-dna complex]]
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