3ivb: Difference between revisions
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{{STRUCTURE_3ivb| PDB=3ivb | SCENE= }} | {{STRUCTURE_3ivb| PDB=3ivb | SCENE= }} | ||
===Structures of SPOP-Substrate Complexes: Insights into Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-MacroH2ASBCpep1=== | ===Structures of SPOP-Substrate Complexes: Insights into Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-MacroH2ASBCpep1=== | ||
{{ABSTRACT_PUBMED_019818708}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SPOP_HUMAN SPOP_HUMAN]] Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.<ref>PMID:14528312</ref><ref>PMID:15897469</ref><ref>PMID:16524876</ref> [[http://www.uniprot.org/uniprot/H2AY_HUMAN H2AY_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.<ref>PMID:12718888</ref><ref>PMID:15621527</ref><ref>PMID:15897469</ref><ref>PMID:16428466</ref><ref>PMID:16107708</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3ivb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVB OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:019818708</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Calabrese, M F.]] | [[Category: Calabrese, M F.]] | ||
| Line 20: | Line 16: | ||
[[Category: Schulman, B A.]] | [[Category: Schulman, B A.]] | ||
[[Category: Seyedin, S.]] | [[Category: Seyedin, S.]] | ||
[[Category: Chromatin regulator]] | [[Category: Chromatin regulator]] | ||
[[Category: Chromosomal protein]] | [[Category: Chromosomal protein]] | ||
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[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Protein binding/hydrolase]] | [[Category: Protein binding/hydrolase]] | ||
[[Category: Ubl conjugation pathway]] | [[Category: Ubl conjugation pathway]] | ||
