2yba: Difference between revisions

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[[Image:2yba.png|left|200px]]
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{{STRUCTURE_2yba|  PDB=2yba  |  SCENE=  }}  
{{STRUCTURE_2yba|  PDB=2yba  |  SCENE=  }}  
===CRYSTAL STRUCTURE OF NURF55 IN COMPLEX WITH HISTONE H3===
===CRYSTAL STRUCTURE OF NURF55 IN COMPLEX WITH HISTONE H3===
{{ABSTRACT_PUBMED_21549310}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/CAF1_DROME CAF1_DROME]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development. Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2.<ref>PMID:8887645</ref><ref>PMID:9419341</ref><ref>PMID:9784495</ref><ref>PMID:12490953</ref><ref>PMID:15456884</ref>  
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{{ABSTRACT_PUBMED_21549310}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:021549310</ref><references group="xtra"/>
<ref group="xtra">PMID:021549310</ref><references group="xtra"/><references/>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Aiwazian, J.]]
[[Category: Aiwazian, J.]]
Line 46: Line 34:
[[Category: Zhao, K.]]
[[Category: Zhao, K.]]
[[Category: Zhou, S.]]
[[Category: Zhou, S.]]
[[Category: Chromatin remodelling]]
[[Category: H3k4]]
[[Category: Histone methylation h3k27]]
[[Category: Polycomb]]
[[Category: Prc2]]
[[Category: Rbap46]]
[[Category: Rbap48]]
[[Category: Rbbp4]]
[[Category: Rbbp7]]
[[Category: Transcription]]
[[Category: Wd40 domain]]

Revision as of 09:40, 27 March 2013

Template:STRUCTURE 2yba

CRYSTAL STRUCTURE OF NURF55 IN COMPLEX WITH HISTONE H3

Template:ABSTRACT PUBMED 21549310

Function

[CAF1_DROME] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development. Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2.[1][2][3][4][5]

About this Structure

2yba is a 4 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

  1. Schmitges FW, Prusty AB, Faty M, Stutzer A, Lingaraju GM, Aiwazian J, Sack R, Hess D, Li L, Zhou S, Bunker RD, Wirth U, Bouwmeester T, Bauer A, Ly-Hartig N, Zhao K, Chan H, Gu J, Gut H, Fischle W, Muller J, Thoma NH. Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks. Mol Cell. 2011 May 6;42(3):330-41. PMID:21549310 doi:10.1016/j.molcel.2011.03.025
  1. ↑ Tyler JK, Bulger M, Kamakaka RT, Kobayashi R, Kadonaga JT. The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Mol Cell Biol. 1996 Nov;16(11):6149-59. PMID:8887645
  2. ↑ Martinez-Balbas MA, Tsukiyama T, Gdula D, Wu C. Drosophila NURF-55, a WD repeat protein involved in histone metabolism. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):132-7. PMID:9419341
  3. ↑ Gdula DA, Sandaltzopoulos R, Tsukiyama T, Ossipow V, Wu C. Inorganic pyrophosphatase is a component of the Drosophila nucleosome remodeling factor complex. Genes Dev. 1998 Oct 15;12(20):3206-16. PMID:9784495
  4. ↑ Beall EL, Manak JR, Zhou S, Bell M, Lipsick JS, Botchan MR. Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Nature. 2002 Dec 19-26;420(6917):833-7. PMID:12490953 doi:10.1038/nature01228
  5. ↑ Taylor-Harding B, Binne UK, Korenjak M, Brehm A, Dyson NJ. p55, the Drosophila ortholog of RbAp46/RbAp48, is required for the repression of dE2F2/RBF-regulated genes. Mol Cell Biol. 2004 Oct;24(20):9124-36. PMID:15456884 doi:10.1128/MCB.24.20.9124-9136.2004

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