Sandbox Reserved 595: Difference between revisions
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=Function= | =Function= | ||
==Lipid Metabolism== | |||
==Immunological== | |||
ApoE can bind lipid antigens. Once binding occurs, apoE delivers the antigens, via receptor-mediated uptake, into endosomal compartments containing CD1 in antigen-processing cells. This protein can be secreted by antigen-presenting cells for the purpose of surveying the local environment and transfer microbial lipids from infected cells to bystander antigen-presenting cells. In one study, apoE mediated the presentation of serum-bovine lipid antigens. In this way, the immune system has co-opted a component of lipid metabolism in order to raise immunologic responses to lipid antigens (W). | |||
=Clinical Relevance= | =Clinical Relevance= | ||
=References= | =References= | ||
