3zkf: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of LC8 in complex with Nek9 phosphopeptide===

~~The entry 3zkf is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/DYL1_HUMAN DYL1_HUMAN]] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.<ref>PMID:10198631</ref> <ref>PMID:15193260</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref> Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.<ref>PMID:10198631</ref> <ref>PMID:15193260</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref> Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.<ref>PMID:10198631</ref> <ref>PMID:15193260</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref> Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.<ref>PMID:10198631</ref> <ref>PMID:15193260</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref>

~~Authors~~: ~~Gallego, P~~.~~, Velazquez-Campoy, A~~.~~, Regue, L~~.~~, Roig, J~~.~~, Reverter, D~~.

==About this Structure==

[[3zkf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharothrix_mutabilis Saccharothrix mutabilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZKF OCA].

~~Description~~: ~~Structure of LC8 in~~ complex ~~with Nek9 phosphopeptide~~

==Reference==

[[Category: Saccharothrix mutabilis]]

[[Category: Gallego, P.]]

[[Category: Regue, L.]]

[[Category: Reverter, D.]]

[[Category: Roig, J.]]

[[Category: Velazquez-Campoy, A.]]

[[Category: Contractile protein-peptide complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_3zkf|  PDB=3zkf  |  SCENE=  }}
+===Structure of LC8 in complex with Nek9 phosphopeptide===
+{{ABSTRACT_PUBMED_23482567}}
-The entry 3zkf is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/DYL1_HUMAN DYL1_HUMAN]] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.<ref>PMID:10198631</ref> <ref>PMID:15193260</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref>   Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.<ref>PMID:10198631</ref> <ref>PMID:15193260</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref>   Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.<ref>PMID:10198631</ref> <ref>PMID:15193260</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref>   Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.<ref>PMID:10198631</ref> <ref>PMID:15193260</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref>
-Authors: Gallego, P., Velazquez-Campoy, A., Regue, L., Roig, J., Reverter, D.
+==About this Structure==
+[[3zkf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharothrix_mutabilis Saccharothrix mutabilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZKF OCA].
-Description: Structure of LC8 in complex with Nek9 phosphopeptide
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Saccharothrix mutabilis]]
+[[Category: Gallego, P.]]
+[[Category: Regue, L.]]
+[[Category: Reverter, D.]]
+[[Category: Roig, J.]]
+[[Category: Velazquez-Campoy, A.]]
+[[Category: Contractile protein-peptide complex]]