3w3n: Difference between revisions
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{{STRUCTURE_3w3n| PDB=3w3n | SCENE= }} | |||
===Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 3=== | |||
{{ABSTRACT_PUBMED_23520111}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref> | |||
==About this Structure== | |||
[[3w3n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W3N OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Ohto, U.]] | |||
[[Category: Shimizu, T.]] | |||
[[Category: Tanji, H.]] | |||
[[Category: Antivirus and antitumor drug]] | |||
[[Category: Antivirus and antitumor drug binding]] | |||
[[Category: Glycosylation]] | |||
[[Category: Immune system]] | |||
[[Category: Innate immunity]] | |||
[[Category: Leucine rich repeat]] | |||
[[Category: Receptor]] | |||
[[Category: Resiquimod]] | |||
[[Category: Rna]] | |||
[[Category: Rna binding]] | |||
[[Category: Rna receptor]] | |||
[[Category: Rna recognition]] | |||
[[Category: Secreted]] | |||
[[Category: Ssrna]] | |||
Revision as of 01:31, 4 April 2013
Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 3
Template:ABSTRACT PUBMED 23520111
Function
[TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.[1]
About this Structure
3w3n is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Doyle SL, Jefferies CA, Feighery C, O'Neill LA. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem. 2007 Dec 21;282(51):36953-60. Epub 2007 Oct 11. PMID:17932028 doi:10.1074/jbc.M707682200
