4hjp: Difference between revisions
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{{STRUCTURE_4hjp| PDB=4hjp | SCENE= }} | |||
===SHP-1 catalytic domain WPD loop open=== | |||
{{ABSTRACT_PUBMED_23514039}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN]] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref> | |||
==About this Structure== | |||
[[4hjp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HJP OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Protein-tyrosine-phosphatase]] | |||
[[Category: Alicea-Velazquez, N L.]] | |||
[[Category: Boggon, T J.]] | |||
[[Category: Hydrolase]] | |||
[[Category: Phosphatase domain]] | |||
