1mr0: Difference between revisions
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==Disease== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/AGRP_HUMAN AGRP_HUMAN]] Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:[http://omim.org/entry/601665 601665]]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:12213871</ref> | [[http://www.uniprot.org/uniprot/AGRP_HUMAN AGRP_HUMAN]] Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:[http://omim.org/entry/601665 601665]]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:12213871</ref> | ||
==Function== | ==Function== | ||
[[http://www.uniprot.org/uniprot/AGRP_HUMAN AGRP_HUMAN]] Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.<ref>PMID:9892020</ref><ref>PMID:11145747</ref><ref>PMID:17041250</ref><ref>PMID:10371151</ref><ref>PMID:15927146</ref> | [[http://www.uniprot.org/uniprot/AGRP_HUMAN AGRP_HUMAN]] Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.<ref>PMID:9892020</ref> <ref>PMID:11145747</ref> <ref>PMID:17041250</ref> <ref>PMID:10371151</ref> <ref>PMID:15927146</ref> | ||
==About this Structure== | ==About this Structure== | ||
