3k64: Difference between revisions
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{{STRUCTURE_3k64| PDB=3k64 | SCENE= }} | {{STRUCTURE_3k64| PDB=3k64 | SCENE= }} | ||
===Crystal structure of FBF-2/fem-3 PME complex=== | ===Crystal structure of FBF-2/fem-3 PME complex=== | ||
{{ABSTRACT_PUBMED_19901328}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FBF2_CAEEL FBF2_CAEEL]] Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression possibly by directly binding to two sites within the gld-3 isoform B 3'-UTR.<ref>PMID:9393998</ref> <ref>PMID:15454534</ref> | |||
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==About this Structure== | ==About this Structure== | ||
[[3k64]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K64 OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:019901328</ref><references group="xtra"/><references/> | ||
[[Category: Caenorhabditis elegans]] | [[Category: Caenorhabditis elegans]] | ||
[[Category: Hall, T M.T.]] | [[Category: Hall, T M.T.]] | ||
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[[Category: Puf]] | [[Category: Puf]] | ||
[[Category: Rna-binding specificity]] | [[Category: Rna-binding specificity]] | ||
[[Category: Rna-rna binding protein complex]] | |||
Revision as of 02:02, 4 April 2013
Crystal structure of FBF-2/fem-3 PME complex
Template:ABSTRACT PUBMED 19901328
Function
[FBF2_CAEEL] Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression possibly by directly binding to two sites within the gld-3 isoform B 3'-UTR.[1] [2]
About this Structure
3k64 is a 2 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.
Reference
- Wang Y, Opperman L, Wickens M, Hall TM. Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20186-91. Epub 2009 Nov 9. PMID:19901328
- ↑ Zhang B, Gallegos M, Puoti A, Durkin E, Fields S, Kimble J, Wickens MP. A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line. Nature. 1997 Dec 4;390(6659):477-84. PMID:9393998 doi:10.1038/37297
- ↑ Eckmann CR, Crittenden SL, Suh N, Kimble J. GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans. Genetics. 2004 Sep;168(1):147-60. PMID:15454534 doi:10.1534/genetics.104.029264
